Synthesis of new pyridazinone derivatives:: 2,6-disubstituted 5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters

被引：7

作者：

Li, Lian-Sheng ^{[1
]}

Zhou, Yuefen ^{[1
]}

Zhao, Jingjing ^{[1
]}

Dragovich, Peter S. ^{[1
]}

Stankovic, Nebojsa ^{[1
]}

Bertolini, Thomas M. ^{[1
]}

Murphy, Douglas E. ^{[1
]}

Sun, Zhongxiang ^{[1
]}

Tran, Chinh V. ^{[1
]}

Ayida, Benjamin K. ^{[1
]}

Ruebsam, Frank ^{[1
]}

Webber, Stephen E. ^{[1
]}

机构：

[1] Anadys Pharmaceut, San Diego, CA 92121 USA

来源：

SYNTHESIS-STUTTGART | 2007年 / 21期

关键词：

alpha-keto esters; acylation; hydrazones; Dieckmann cyclization; pyridazinones;

D O I：

10.1055/s-2007-990823

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,6-Disubstituted 5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from alpha-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cyclization.

引用

收藏

页码：3301 / 3308

页数：8

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