Photolabile group for 5′-OH protection of nucleosides:: synthesis and photodeprotection rate

被引：21

作者：

Berroy, P ^{[1
]}

Viriot, ML ^{[1
]}

Carré, MC ^{[1
]}

机构：

[1] ENSIC, CNRS, INPL,UMR 7630, GRAPP,Dept Chim Phys React, F-54000 Nancy, France

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2001年 / 74卷 / 1-3期

关键词：

photolabile groups; protection of deoxynucleosides; photolysis; DNA array;

D O I：

10.1016/S0925-4005(00)00731-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this paper, we described the properties of a new photolabile group, 2-(3,4-methylenedioxy-6-nitrophenyl)propoxycarbonayl MNPPOC. In spite of moderate yields of synthesis, photolytic properties could be analyzed for 5 ' -OH protected T and dA(iBU). The half-lives (t(1/2)) 11 and 12 s were found, respectively with a good recovery of the corresponding deprotected deoxynucleoside (95-99%). The photolysis rate of this new photolabile group was five-fold faster than the MeNPOC one. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：186 / 189

页数：4

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