Corticotropin-releasing factor induction in rat piriform cortex following kainate-elicited seizures

被引：10

作者：

Piekut, DT

Phipps, B

机构：

[1] Dept. of Neurobiology and Anatomy, Univ. of Rochester Sch. of Medicine, Rochester

来源：

NEUROSCIENCE LETTERS | 1996年 / 209卷 / 01期

关键词：

corticotropin-releasing factor; piriform cortex; seizures; kainic acid; rat;

D O I：

10.1016/0304-3940(96)12608-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is a substantial increase in number of cells labeled for corticotropin-releasing factor-like immunoreactivity in specific extrahypothalamic brain regions, particularly the piriform cortex, in rats allowed to survive 24 h following generalized clonic seizures. Seizures were elicited by kainic acid. Vehicle treated control animals had only a few cells labeled for corticotropin-releasing factor-like immunoreactivity at these brain sites. These areas of corticotropin-releasing factor-like induction appear to be localized to brain regions known to be vulnerable to kainate neurotoxicity and cell destruction.

引用

页码：45 / 48

页数：4

共 18 条

[1] PEPTIDE-INDUCED INFANT STATUS EPILEPTICUS CAUSES NEURONAL DEATH AND SYNAPTIC REORGANIZATION [J].