CORTICOTROPIN RELEASING-FACTOR ANTAGONIST REDUCES ISCHEMIC HIPPOCAMPAL NEURONAL INJURY

被引：67

作者：

LYONS, MK

ANDERSON, RE

MEYER, FB

机构：

[1] MAYO CLIN & MAYO FDN, DEPT NEUROL SURG, CEREBRAL VASC RES LAB, 200 1ST ST SW, ROCHESTER, MN 55905 USA

[2] MAYO CLIN & MAYO GRAD SCH MED, ROCHESTER, MN 55901 USA

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

CORTICOTROPIN-RELEASING FACTOR; NEURON; ANTAGONIST; ELECTROENCEPHALOGRAM; ISCHEMIA; HIPPOCAMPUS;

D O I：

10.1016/0006-8993(91)91310-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

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页码：339 / 342

页数：4

相关论文

共 32 条

[1] DOES CORTICOTROPIN RELEASING-FACTOR ACT VIA A CALCIUM-DEPENDENT MECHANISM [J].

ALDENHOFF, JB .

PSYCHONEUROENDOCRINOLOGY, 1986, 11 (02) :231-236

[2] CORTICOTROPIN RELEASING-FACTOR DECREASES POSTBURST HYPERPOLARIZATIONS AND EXCITES HIPPOCAMPAL-NEURONS [J].

ALDENHOFF, JB ;

GRUOL, DL ;

RIVIER, J ;

VALE, W ;

SIGGINS, GR .

SCIENCE, 1983, 221 (4613) :875-877

[3] CORTICOTROPIN RELEASING-FACTOR (CRF) RECEPTOR ANTAGONIST BLOCKS ACTIVATING AND ANXIOGENIC ACTIONS OF CRF IN THE RAT [J].

BRITTON, KT ;

LEE, G ;

VALE, W ;

RIVIER, J ;

KOOB, GF .

BRAIN RESEARCH, 1986, 369 (1-2) :303-306

[4]

BROWN AW, 1968, BRIT J EXP PATHOL, V49, P87

[5] EFFECTS OF CORTICOTROPIN RELEASING-FACTOR ON LOCOMOTOR-ACTIVITY IN HYPOPHYSECTOMIZED RATS [J].

EAVES, M ;

THATCHERBRITTON, K ;

RIVIER, J ;

VALE, W ;

KOOB, GF .

PEPTIDES, 1985, 6 (05) :923-926

[6] CORTICOTROPIN RELEASING-FACTOR PRODUCES INCREASES IN BRAIN EXCITABILITY AND CONVULSIVE SEIZURES IN RATS [J].

EHLERS, CL ;

HENRIKSEN, SJ ;

WANG, M ;

RIVIER, J ;

VALE, W ;

BLOOM, FE .

BRAIN RESEARCH, 1983, 278 (1-2) :332-336

[7] CRF ANTAGONIST PARTIALLY REVERSES CRF-INDUCED AND STRESS-INDUCED EFFECTS ON FEEDING [J].

KRAHN, DD ;

GOSNELL, BA ;

GRACE, M ;

LEVINE, AS .

BRAIN RESEARCH BULLETIN, 1986, 17 (03) :285-289

[8] STRESS-INDUCED GASTROINTESTINAL SECRETORY AND MOTOR-RESPONSES IN RATS ARE MEDIATED BY ENDOGENOUS CORTICOTROPIN-RELEASING FACTOR [J].

LENZ, HJ ;

RAEDLER, A ;

GRETEN, H ;

VALE, WW ;

RIVIER, JE .

GASTROENTEROLOGY, 1988, 95 (06) :1510-1517

[9] DIFFERENT EPILEPTOGENIC ACTIVITIES OF MURINE AND OVINE CORTICOTROPIN-RELEASING FACTOR [J].

MARROSU, F ;

MEREU, G ;

FRATTA, W ;

CARCANGIU, P ;

CAMARRI, F ;

GESSA, GL .

BRAIN RESEARCH, 1987, 408 (1-2) :394-398

[10] LOCALIZED EPILEPTIFORM ACTIVITY INDUCED BY MURINE CRF IN RATS [J].

MARROSU, F ;

FRATTA, W ;

CARCANGIU, P ;

GIAGHEDDU, M ;

GESSA, GL .

EPILEPSIA, 1988, 29 (04) :369-373

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