Use of genome-scale microbial models for metabolic engineering

被引：111

作者：

Patil, KR ^{[1
]}

Åkesson, M ^{[1
]}

Nielsen, J ^{[1
]}

机构：

[1] Tech Univ Denmark, Bioctr, Ctr Proc Biotechnol, DK-2800 Lyngby, Denmark

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2004年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.copbio.2003.11.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.

引用

页码：64 / 69

页数：6

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