Vitamin A Metabolism and Adipose Tissue Biology

被引：79

作者：

Frey, Simone K.

Vogel, Silke ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

来源：

NUTRIENTS | 2011年 / 3卷 / 01期

关键词：

retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis; RETINOL-BINDING-PROTEIN; SHORT-CHAIN DEHYDROGENASES/REDUCTASES; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION; ACTIVATED RECEPTOR; BETA-CAROTENE; ACYLTRANSFERASE GENE; LIPID-METABOLISM; SERUM RETINOL; PPAR-GAMMA;

D O I：

10.3390/nu3010027

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.

引用

收藏

页码：27 / 39

页数：13

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