The natural history of type 1A diabetes

被引：35

作者：

Eisenbarth, George S. ^{[1
]}

Jeffrey, Joy ^{[1
]}

机构：

[1] Hlth Sci Ctr, Aurora, CO USA

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2008年 / 52卷 / 02期

关键词：

type; 1; diabetes; anti-islet autoimmunity; autoantibodies; HLA; genetic;

D O I：

10.1590/S0004-27302008000200002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.

引用

页码：146 / 155

页数：10

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