Clostridial toxins: Molecular probes of Rho-dependent signaling and apoptosis

被引：6

作者：

Bobak, DA

机构：

[1] Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Microbiol, Charlottesville, VA 22908 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1999年 / 193卷 / 1-2期

关键词：

Rho; GTPase; toxins; Clostridium; signal transduction; apoptosis;

D O I：

10.1023/A:1006939505896

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Rho family small GTPases are members of the Ras superfamily of small GTPases. Rho proteins were first determined to act as key regulators of many types of actin cytoskeletal-dependent cellular functions. Recent work by several investigators indicates that Rho GTPases are also critical modulators of several important intracellular and nuclear signal transduction pathways. Certain clostridial toxins and exoenzymes covalently modify, and thereby inactivate, specific types of Rho family GTPases. As such, these microbial enzymes have proven invaluable in helping to identify structural and functional attributes of Rho GTPases.

引用

页码：37 / 42

页数：6

共 29 条

[1] MONOGLUCOSYLATION OF LOW-MOLECULAR-MASS GTP-BINDING RHO PROTEINS BY CLOSTRIDIAL CYTOTOXINS [J].