Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems

被引：60

作者：

Pardridge, WM ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY | 1999年 / 2卷 / 02期

关键词：

D O I：

10.1016/S1461-5347(98)00117-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Brain drug development is limited by the blood-brain barrier (BBB), which restricts the passage into the brain of >95% of all drug candidates intended for the CNS. The growth of future CNS drug development can be accelerated by fostering parallel growth in both CNS drug discovery and CNS drug delivery One approach to solving the BBB problem is to target endogenous BBB transport systems, and to develop CNS drug delivery strategies that take advantage of these natural portals of entry into the brain.

引用

页码：49 / 59

页数：11

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