Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles

被引：144

作者：

Hall, Brett

Dembinski, Jennifer

Sasser, A. Kate

Studeny, Matus

Andreeff, Michael

Marini, Frank

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Unit 81, Houston, TX 77030 USA

[2] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA

[3] Columbus Childrens Res Inst, Ctr Childhood Canc, Columbus, OH USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 01期

关键词：

mesenchymal stem cells; tumor microenvironment; stroma; vascular network; gene therapy;

D O I：

10.1532/IJH97.06230

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anticancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

引用

页码：8 / 16

页数：9

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