Specifying positional information in the embryo: Looking beyond morphogens

被引:113
作者
Kerszberg, Michel
Wolpert, Lewis
机构
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
[2] Univ Paris 06, UMR 7138, CNRS, Paris, France
关键词
D O I
10.1016/j.cell.2007.06.038
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Concentration gradients of small diffusible molecules called morphogens are key regulators of development, specifying position during pattern formation in the embryo. It is now becoming clear that additional or alternative mechanisms involving interactions among cells are also crucial for positional specification.
引用
收藏
页码:205 / 209
页数:5
相关论文
共 37 条
[1]   Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster [J].
Baena-Lopez, L. A. ;
Garcia-Bellido, A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (37) :13734-13739
[2]   A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube [J].
Briscoe, J ;
Chen, Y ;
Jessell, TM ;
Struhl, G .
MOLECULAR CELL, 2001, 7 (06) :1279-1291
[3]   DIFFUSION IN EMBRYOGENESIS [J].
CRICK, F .
NATURE, 1970, 225 (5231) :420-&
[4]   A GRADIENT OF BICOID PROTEIN IN DROSOPHILA EMBRYOS [J].
DRIEVER, W ;
NUSSLEINVOLHARD, C .
CELL, 1988, 54 (01) :83-93
[5]   Coupling segmentation to axis formation [J].
Dubrulle, J ;
Pourquié, O .
DEVELOPMENT, 2004, 131 (23) :5783-5793
[6]   Gradient formation of the TGF-β homolog Dpp [J].
Entchev, EV ;
Schwabedissen, A ;
González-Gaitán, M .
CELL, 2000, 103 (06) :981-991
[7]   Regulatory principles of developmental signaling [J].
Freeman, M ;
Gurdon, JB .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2002, 18 :515-539
[8]   Probing the limits to positional information [J].
Gregor, Thomas ;
Tank, David W. ;
Wieschaus, Eric F. ;
Bialek, William .
CELL, 2007, 130 (01) :153-164
[9]   Stability and nuclear dynamics of the bicoid morphogen gradient [J].
Gregor, Thomas ;
Wieschaus, Eric F. ;
McGregor, Alistair P. ;
Bialek, William ;
Tank, David W. .
CELL, 2007, 130 (01) :141-152
[10]   Morphogen gradient interpretation [J].
Gurdon, JB ;
Bourillot, PY .
NATURE, 2001, 413 (6858) :797-803