Variations in yeast 3′-processing cis-elements correlate with transcript stability

被引：18

作者：

Graber, JH ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 09期

关键词：

D O I：

10.1016/S0168-9525(03)00196-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A large set of yeast mRNA 3'-processing regulatory sequences was analyzed statistically, revealing a systematic variation that correlates with measured mRNA stability. Transcripts with relatively short half-lives have a high frequency of inclusion of 3'-processing elements that include the core sequence of binding sites for the PUF proteins, which enhance mRNA turnover. These results suggest that regulatory sequence variation, typically modeled as random, could arise instead from the necessity or advantage of specifying multiple functions in a common sequence element.

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页码：473 / 476

页数：4

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