Pertussis: an important target for maternal immunization

被引：38

作者：

Edwards, KM ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Pediat, Vice Chair Clin Res, Nashville, TN 37240 USA

来源：

VACCINE | 2003年 / 21卷 / 24期

关键词：

extracorporeal membrane oxygenation; tranplacental; immunogenic;

D O I：

10.1016/S0264-410X(03)00356-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cord blood antipertussis IgG concentrations were measured in infants and were found to be nearly equal to maternal levels. By 4 months of age most infants had no measurable antibody to pertussis toxin (PT) or filamentous hemagglutinin. Higher concentrations of maternally derived antibody to PT were associated with a weaker pertussis toxin antibody response to whole cell pertussis vaccine, but not to a cellular vaccine. These studies suggest that maternal immunization would provide early protection of the newborn to allow time for the primary immunization schedule at 2, 4, and 6 months of age to induce more durable protection. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3483 / 3486

页数：4

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