New insights into the link between cardiovascular disease and depression

被引：52

作者：

Mosovich, S. A. ^{[1
]}

Boone, R. T. ^{[2
]}

Reichenberg, A. ^{[1
]}

Bansilal, S. ^{[1
]}

Shaffer, J. ^{[3
]}

Dahlman, K. ^{[1
]}

Harvey, P. D. ^{[4
]}

Farkouh, M. E. ^{[5
]}

机构：

[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[2] Univ Massachusetts, Dept Psychol, Dartmouth, MA USA

[3] St Johns Univ, Dept Psychol, Jamaica, NY 11439 USA

[4] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[5] Mt Sinai Sch Med, Dept Cardiol, New York, NY USA

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2008年 / 62卷 / 03期

关键词：

D O I：

10.1111/j.1742-1241.2007.01640.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Although the association between depression and cardiovascular disease (CVD) is well documented, the underlying mechanisms for this relationship remain unclear. In this paper, we present three possible models which account for the comorbidity between depression and cardiovascular disease. Models: The first model outlines depression as a risk factor for CVD and the second model presents CVD as a risk factor for depression. The third model proposes a common underlying pathway related to the effects of chronic stress on the body in manifesting as depression or cardiovascular disease. Conclusions: If the proposed model holds true, it may be possible that an intervention initiated before overt manifestations of CVD or depression become apparent, may delay or prevent the onset of these serious clinical entities.

引用

页码：423 / 432

页数：10

共 81 条

[51] INCREASED NEOPTERIN AND INTERFERON-GAMMA SECRETION AND LOWER AVAILABILITY OF L-TRYPTOPHAN IN MAJOR DEPRESSION - FURTHER EVIDENCE FOR AN IMMUNE-RESPONSE [J].