Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks

被引：36

作者：

Rong, Yikang S. ^{[1
]}

机构：

[1] NCI, NIH, Biochem & Mol Biol Lab, Bethesda, MD 20892 USA

来源：

CHROMOSOMA | 2008年 / 117卷 / 03期

关键词：

D O I：

10.1007/s00412-007-0144-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere caps prevent chromosome ends from being recognized as DNA double-strand breaks (DSBs). Unlike most organisms studied, the telomere-capping function of Drosophila does not require a specific sequence. Without this sequence component, Drosophila telomeres most resemble DNA breaks and, thus, represent a simpler system for the study of telomere capping. I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance.

引用

页码：235 / 242

页数：8

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