Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks

被引：36

作者：

Rong, Yikang S. ^{[1
]}

机构：

[1] NCI, NIH, Biochem & Mol Biol Lab, Bethesda, MD 20892 USA

来源：

CHROMOSOMA | 2008年 / 117卷 / 03期

关键词：

D O I：

10.1007/s00412-007-0144-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere caps prevent chromosome ends from being recognized as DNA double-strand breaks (DSBs). Unlike most organisms studied, the telomere-capping function of Drosophila does not require a specific sequence. Without this sequence component, Drosophila telomeres most resemble DNA breaks and, thus, represent a simpler system for the study of telomere capping. I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance.

引用

页码：235 / 242

页数：8

共 54 条

[51] ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis [J].

Vespa, L ;

Couvillion, M ;

Spangler, E ;

Shippen, DE .

GENES & DEVELOPMENT, 2005, 19 (18) :2111-2115

[52] NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants [J].

Waterworth, Wanda M. ;

Altun, Cagla ;

Armstrong, Susan J. ;

Roberts, Nicola ;

Dean, Philip J. ;

Young, Kim ;

Weil, Clifford F. ;

Bray, Clifford M. ;

West, Christopher E. .

PLANT JOURNAL, 2007, 52 (01) :41-52

[53] Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells [J].

Yamaguchi-Iwai, Y ;

Sonoda, E ;

Sasaki, MS ;

Morrison, C ;

Haraguchi, T ;

Hiraoka, Y ;

Yamashita, YM ;

Yagi, T ;

Takata, M ;

Price, C ;

Kakazu, N ;

Takeda, S .

EMBO JOURNAL, 1999, 18 (23) :6619-6629

[54] Linear chromosome maintenance in the absence of essential telomere-capping proteins [J].

Zubko, Mikhajlo K. ;

Lydall, David .

NATURE CELL BIOLOGY, 2006, 8 (07) :734-740

← 1 2 3 4 5 6 →