Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes

被引：153

作者：

Zwart, R

Sleutels, F

Wutz, A

Schinkel, AH

Barlow, DP ^{[1
]}

机构：

[1] OAW Inst Mol Biol, A-5020 Salzburg, Austria

[2] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[3] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

GENES & DEVELOPMENT | 2001年 / 15卷 / 18期

关键词：

Slc22a3-Orct3-EMT; Slc22a2-Orct2; Igf2r; genomic imprinting;

D O I：

10.1101/gad.206201

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Imprinting of the maternally-expressed Igf2r gene is controlled by an intronic imprint control element (ICE) known as Region2 that contains the promoter of the noncoding Air RNA, whose transcript overlaps the silenced paternal Igf2r promoter in an antisense orientation. Two novel imprinted genes, Slc22a2 and Slc22a3 are described here that lie 110 and 155 kb 3 ' to Igf2r and that are not overlapped by the Air transcript but are regulated by the Igf2r-ICE, as previously shown for Igf2r. These results identify a new cluster of imprinted genes whose repression by the bidirectional action of the Region2-ICE is independent of transcript overlap by the Air RNA.

引用

收藏

页码：2361 / 2366

页数：6

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