Stereoselective synthesis of new bicyclic N,O-iso-homonucleoside analogues

被引：24

作者：

Richichi, B

Cicchi, S

Chiacchio, U

Romeo, G

Brandi, A

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Florence, Italy

[2] Univ Messina, Dipartimento Farmacochim, I-98100 Messina, Italy

[3] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

TETRAHEDRON | 2003年 / 59卷 / 28期

关键词：

nucleoside analogues; 1,3-dipolar cycloaddition; Mitsunobu reaction;

D O I：

10.1016/S0040-4020(03)00772-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two new bicyclic nucleoside analogues is reported. These compounds are iso-homonucleoside and are synthesised through a 1,3-dipolar cycloaddition of an enantiopure cyclic nitrone to protected allyl acohol and subsequent introduction of thymine by a Mitsunobu reaction. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：5231 / 5240

页数：10

共 49 条

[1] SYNTHESIS OF CARBOCYCLIC NUCLEOSIDES [J].