New limits in ultrasensitive trace detection by surface enhanced Raman scattering (SERS)

被引:109
作者
Etchegoin, P
Maher, RC
Cohen, LF
Hartigan, H
Brown, RJC
Milton, MJT
Gallop, JC
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Phys, Blackett Lab, London SW7 2BW, England
[2] Natl Phys Lab, Teddington TW11 0LW, Middx, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1016/S0009-2614(03)00821-2
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We show the possibility of chemical tracing in solution down to a concentration of a fraction of an atto mol (10(-18)) by means of non-resonant surface enhanced Raman scattering (SERS). The experiments are demonstrated with rhodamine 6G dissolved in water. Based on our results here, we propose a technique for counting a small number of SERS active molecules in micro-droplets of liquid. It is argued that, by choosing the appropriate SERS enhancement condition, the technique could be used and implemented as a routine analytical method with unprecedented detection capabilities for the monitoring and tracing of important families of biomolecules. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:84 / 90
页数:7
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