Catalytic Asymmetric Epoxidation of α-Branched Enals

被引：132

作者：

Lifchits, Olga ^{[1
]}

Reisinger, Corinna M. ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 30期

关键词：

ALPHA; BETA-UNSATURATED KETONES; ORGANOCATALYTIC EPOXIDATION; NUCLEOPHILIC CARBENE; HYDROGEN-PEROXIDE; EPOXY-ALCOHOLS; ALDEHYDES; ALKENES; ACYLOXYACROLEINS; EPOXIDES; ENONES;

D O I：

10.1021/ja1037935

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An asymmetric catalytic epoxidation of alpha-branched, alpha,beta-unsaturated aldehydes is presented. A highly synergistic combination of a primary cinchona-based amine and a chiral phosphoric acid was found to promote the reaction with excellent enantiocontrol for alpha-monosubstituted and alpha,beta-disubstituted enals.

引用

页码：10227 / 10229

页数：3

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