Rho kinase, a promising drug target for neurological disorders

被引：511

作者：

Mueller, BK ^{[1
]}

Mack, H ^{[1
]}

Teusch, N ^{[1
]}

机构：

[1] Abbott GmbH & Co KG, D-67061 Ludwigshafen, Germany

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 05期

关键词：

D O I：

10.1038/nrd1719

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rho kinases (ROCKs), the first Rho effectors to be described, are serine/threonine kinases that are important in fundamental processes of cell migration, cell proliferation and cell survival. Abnormal activation of the Rho/ROCK pathway has been observed in various disorders of the central nervous system. Injury to the adult vertebrate brain and spinal cord activates ROCKs, thereby inhibiting neurite growth and sprouting. Inhibition of ROCKs results in accelerated regeneration and enhanced functional recovery after spinal-cord injury in mammals, and inhibition of the Rho/ROCK pathway has also proved to be efficacious in animal models of stroke, inflammatory and demyelinating diseases, Alzheimer's disease and neuropathic pain. ROCK inhibitors therefore have potential for preventing neurodegeneration and stimulating neuroregeneration in various neurological disorders.

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页码：387 / 398

页数：12

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