Ligand-Free Copper-Catalyzed Arylation of Amidines

被引：37

作者：

Cortes-Salva, Michelle ^{[1
]}

Garvin, Corey ^{[1
]}

Antilla, Jon C. ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 05期

关键词：

CROSS-COUPLING REACTIONS; ONE-STEP SYNTHESIS; N BOND FORMATION; ARYL IODIDES; CORTICAL-NEURONS; SULFONYL AZIDE; NITRILES; AMINES; BENZIMIDAZOLES; DERIVATIVES;

D O I：

10.1021/jo102235u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free conditions. DMF was the superior solvent for the N-arylation of benzamidines, while MeCN was used in the formation of N-aryl amidines in moderate to high yield.

引用

收藏

页码：1456 / 1459

页数：4

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