Abnormality of very long-chain fatty acids of erythrocyte membrane in alcoholic patients

被引：8

作者：

Adachi, J

Miwa, A

Ueno, Y

Asano, M

Naito, T

Imamichi, H

Tatsuno, Y

机构：

[1] Kobe Univ, Sch Med, Dept Legal Med, Chuo Ku, Kobe, Hyogo 650, Japan

[2] Kobe Pharmaceut Univ, Kobe, Hyogo 658, Japan

[3] Shin Abuyama Hosp, Takatsuki, Osaka, Japan

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1998年 / 22卷 / 03期

关键词：

alcoholic patient; very long-chain fatty acid; erythrocyte membrane; GC-MS;

D O I：

10.1111/acer.1998.22.s3_part1.103s

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Profiles of very long-chain fatty acids were studied in the erythrocyte membrane of five alcoholic patients. We identified three fatty acids as cis-16-pentacosenoic acid (C25:1), cis-17-hexacosenoic acid (C26:1), and hexacosenoic acid (C26:1), and hexacosanoic acid (C26:0) by gas chromatography-mass spectrometry. The ratios of C26:1/C22:0, C26:0/C22:0, C24:1/C22:0, and C24:0/C22:0 were increased. These findings suggest that active oxygen species or free radicals generated by chronic alcohol consumption in alcohol patients interupt the peroxisomal beta-oxidation of fatty acids, because very long-chain fatty acids are mainly metabolized by the peroxisomal beta-oxidation system. This is the first study showing accumulation of very long-chain fatty acids in the erythrocyte membrane of alcoholic patients.

引用

页码：103S / 107S

页数：5

共 13 条

[1] Identification of cholesta-3,5-dien-7-one by gas chromatography mass spectrometry in the erythrocyte membrane of alcoholic patients [J].