Lamotrigine-associated anticonvulsant hypersensitivity syndrome

被引：75

作者：

Schlienger, RG

Knowles, SR

Shear, NH

机构：

[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Clin Pharmacol, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Dermatol, Toronto, ON M4N 3M5, Canada

[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, Canada

[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Pharmacol, Toronto, ON M4N 3M5, Canada

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Pharm, Toronto, ON M4N 3M5, Canada

[6] Univ Toronto, Sunnybrook Hlth Sci Ctr, Glaxo Wellcome Sunnybrook Drug Safety Clin, Toronto, ON M4N 3M5, Canada

来源：

NEUROLOGY | 1998年 / 51卷 / 04期

关键词：

D O I：

10.1212/WNL.51.4.1172

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28 +/- 18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with lamotrigine are comparable to AHS induced by older aromatic anticonvulsants.

引用

页码：1172 / 1175

页数：4

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