N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones:: in vivo active AMPA and NMDA(glycine) antagonists.

被引:31
作者
Auberson, YP [1 ]
Acklin, P [1 ]
Bischoff, S [1 ]
Moretti, R [1 ]
Ofner, S [1 ]
Schmutz, M [1 ]
Veenstra, SJ [1 ]
机构
[1] Novartis Pharma AG, CH-4002 Basel, Switzerland
关键词
D O I
10.1016/S0960-894X(98)00720-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码:249 / 254
页数:6
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