Roles of IL-8 in Ocular Inflammations: A Review

被引：187

作者：

Ghasemi, Hassan ^{[1
]}

Ghazanfari, Tooba

Yaraee, Roya

Faghihzadeh, Soghrat ^{[2
]}

Hassan, Zuhair Mohammad ^{[2
]}

机构：

[1] Shahed Univ, Sch Med, Dept Ophthalmol, Immunoregulat Res Ctr, Tehran, Iran

[2] Tarbiat Modares Univ, Tehran, Iran

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2011年 / 19卷 / 06期

关键词：

angiogenesis; chemokine; cytokine; interleukine-8; ocular inflammation; HUMAN INTERLEUKIN-8 RECEPTOR; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; PROLIFERATIVE DIABETIC-RETINOPATHY; CORNEAL EPITHELIAL-CELLS; GENE-EXPRESSION; CYTOKINE LEVELS; AQUEOUS-HUMOR; INTRAVITREAL BEVACIZUMAB; STAPHYLOCOCCUS-AUREUS;

D O I：

10.3109/09273948.2011.618902

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Introduction: This review presents the current in vitro and in vivo animal and human research on the roles of IL-8 in ocular inflammatory diseases. Materials and Methods: Data sources were a literature review using Pub Med, Medline, and ISI databases (from 1990 to 2011). Search items included interleukine-8 (IL-8), CXCL8, chemokines, cytokines, alone or in combination with the, serum, aqueous, vitreous, eye, ocular, ocular tissues, ophthalmic, and review. Results: IL-8 may be involved in primary or secondary ocular inflammations. Ocular effects of IL-8 differ based on the source of the secretion and site of the action. The most important effects of IL-8 in the eyes are angiogenic activities and induction of ocular inflammation. Conclusion: IL-8 plays important roles in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-8 targeted immunotherapy has been introduced as an important treatment modality, provided that IL-8 signal blocking takes place in desired areas and tissues.

引用

页码：401 / 412

页数：12

共 132 条

[1]

CXC chemokine expression profiles in aqueous humor of patients with different clinical entities of endogenous uveitis [J].