Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity

被引：387

作者：

Sugiyama, Sayaka ^{[2
,7
]}

Di Nardo, Ariel A. ^{[1
]}

Aizawa, Shinichi ^{[3
]}

Matsuo, Isao ^{[4
,5
]}

Volovitch, Michel ^{[1
]}

Prochiantz, Alain ^{[1
,6
]}

Hensch, Takao K. ^{[2
,7
,8
]}

机构：

[1] Ecole Normale Super, CNRS, UMR 8542, F-75230 Paris 05, France

[2] RIKEN Brain Sci Inst, Lab Neuronal Circuit Dev, Wako, Saitama 3510198, Japan

[3] RIKEN, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

[4] Osaka Med Ctr, Dept Mol Embryol, Osaka 5941101, Japan

[5] Res Inst Maternal & Child Hlth, Osaka 5941101, Japan

[6] Coll France, F-75231 Paris, France

[7] Harvard Univ, Sch Med, Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[8] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

CELL | 2008年 / 134卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.05.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing. Conversely, conditional removal of Otx2 from non-PV cells or from the visual pathway abolished plasticity. Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.

引用

页码：508 / 520

页数：13

共 76 条

[61] Developmental plasticity of mouse visual acuity [J].