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Cross-presentation, dendrttic cells, tolerance and immunity

被引：704
作者：
Heath, WR
Carbone, FR
机构：
[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3050, Australia
来源：
ANNUAL REVIEW OF IMMUNOLOGY | 2001年 / 19卷
关键词：
cross-priming; antigen presentation; cytotoxic T lymphocytes; CD8; T cells;
D O I：
10.1146/annurev.immunol.19.1.47
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
引用
收藏
页码：47 / 64
页数：18
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