Cross-presentation, dendrttic cells, tolerance and immunity

被引：704

作者：

Heath, WR

Carbone, FR

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3050, Australia

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2001年 / 19卷

关键词：

cross-priming; antigen presentation; cytotoxic T lymphocytes; CD8; T cells;

D O I：

10.1146/annurev.immunol.19.1.47

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.

引用

页码：47 / 64

页数：18

共 93 条

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