TLRs in Hepatic Cellular Crosstalk

被引：10

作者：

Bigorgne, Amelie E. ^{[1
]}

Crispe, Ian Nicholas ^{[1
,2
]}

机构：

[1] Seattle BioMed, Malaria Program, Seattle, WA 98109 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

GASTROENTEROLOGY RESEARCH AND PRACTICE | 2010年 / 2010卷

关键词：

SINUSOIDAL ENDOTHELIAL-CELLS; TOLL-LIKE RECEPTORS; LIVER-INJURY; C-VIRUS; INFLAMMATORY RESPONSE; KUPFFER CELLS; ACTIVATION; LIPOPOLYSACCHARIDE; DIFFERENTIATION; INVOLVEMENT;

D O I：

10.1155/2010/618260

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Toll-like receptors (TLRs) are expressed on all major subsets of liver cells. Both exogenous ligands derived from pathogens, and endogenous ligands that are products of cellular injury, engage these receptors and activate aspects of innate immunity. These receptors play a role in viral and parasitic infections of the liver, in ischemia-reperfusion injury, and in toxic liver damage, promoting antipathogen immunity but also hepatocellular injury and fibrogenesis. However, TLRs may also participate in negative feedback that limits tissue injury. In the complex environment of the liver, TLRs participate in pathologic cascades involving multiple cell types, manifesting their effects both through cell-autonomous actions, and via cellular crosstalk. In this paper we survey the involvement of TLRs in these diverse processes.

引用

页数：7

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