Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity

被引：13

作者：

Morihira, K

Nishimori, T

Kusama, H

Horiguchi, Y

Kuwajima, I

Tsuruo, T

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

antineoplastics; antitumor compounds; terpenes and terpenoids;

D O I：

10.1016/S0960-894X(98)00539-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The C-aromatic taxoids were synthesized to develop effective inhibitors against drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (278OAD). the benzoate II exhibited significant activity as potent as verapamil, a well-established MDR reversing agent. (C) 1998 Elsevier Science Ltd. Air rights reserved.

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收藏

页码：2973 / 2976

页数：4

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