A hitchhiker's guide to G-quadruplex ligands

被引：682

作者：

Monchaud, David ^{[1
]}

Teulade-Fichou, Marie-Paule ^{[1
]}

机构：

[1] Ctr Univ Paris 11, Sect Rech, CNRS, Inst Curie,UMR 176, F-91405 Orsay, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 04期

关键词：

D O I：

10.1039/b714772b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Over the past decade, nucleic acid chemists have seen the spectacular emergence of molecules designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Initially derived from classical DNA intercalators, these G-quadruplex ligands progressively became the focal point of new excitement since they appear to inhibit selectively the growth of cancer cells thereby opening interesting perspectives towards the development of novel anti-cancer drugs. The present article aims to help researchers enter this exciting research field, and to highlight recent advances in the design of G-quadruplex ligands.

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页码：627 / 636

页数：10

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