Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay

被引：20

作者：

Jäger, AK

Mohoto, SP

van Heerden, FR

Viljoen, AM

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen O, Denmark

[2] Univ Witwatersrand, Fac Hlth Sci, Dept Pharm & Pharmacol, ZA-2193 Johannesburg, South Africa

[3] Rand Afrikaans Univ, Dept Chem & Biochem, ZA-2006 Auckland Pk, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

binding assay; epilepsy; GABA-benzodiazepine receptor; South Africa; sotho traditional medicine;

D O I：

10.1016/j.jep.2004.10.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aqueous and ethanol extracts of six plants, Acrotome inflata, Aptosimum indivisum, Asparagus suaveolens, Barleria bolusii, Commiphora marlothii and Sesamum triphyllum, which constitute an ancient Northern Sotho remedy for epilepsy, Sehlare sa Seebana, was tested in the GABA(A)-benzodiazepine receptor binding assay. Both aqueous and ethanol extracts of Aptosimum indivisum and Asparagus suaveolens and the aqueous extract of Commiphora marlothii showed good dose-dependent activity. The ethanol extract of all six plants extracted together was more active that the aqueous extract. The results did not suggest a synergistic effect of the plant mixture. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：603 / 606

页数：4

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