Tumor necrosis factor-α gene polymorphism at position -308 and schizophrenia in the Korean population

被引：28

作者：

Pae, CU

Chae, JH

Bahk, WM

Han, H

Jun, TY

Kim, KS

Kwon, YS

Serretti, A

机构：

[1] Catholic Univ Korea, Coll Med, Kangnam St Marys Hosp, Dept Psychiat, Seoul, South Korea

[2] Catholic Univ Korea, Coll Med, St Marys Hosp, Dept Psychiat, Seoul, South Korea

[3] Catholic Univ Korea, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea

[4] Catholic Univ Korea, Coll Med, Uijongbu St Marys Hosp, Dept Psychiat, Kyonggi Do, South Korea

[5] Univ Vita Salute San Raffaele, San Raffaele Inst, Dept Psychiat, Milan, Italy

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2003年 / 57卷 / 04期

关键词：

association study; schizophrenia; tumor necrosis factor-alpha gene polymorphism;

D O I：

10.1046/j.1440-1819.2003.01138.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-alpha gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.

引用

页码：399 / 403

页数：5

共 31 条

[1] Impact of the-308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease [J].