A functional approach to questions about life, death, and phosphorylation

被引：6

作者：

Bernards, R

机构：

[1] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands

来源：

CANCER CELL | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2005.05.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The success of the family of kinases as targets for small-molecule cancer therapeutics is probably best illustrated by the efficacy of the drug Gleevec. In spite of this, the function of many of the kinases in the mammalian genome remains unknown. In a recent paper, MacKeigan and colleagues report a functional genetic screen using RNA interference to identify kinases and phosphatases involved in programmed cell death (MacKeigan et al., 2005). Functional annotation is a prerequisite for selection of new drug targets. Such studies may therefore lay the foundation for the next generation of cancer drugs.

引用

页码：503 / 504

页数：2

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