Regulating antigen-receptor gene assembly

被引：119

作者：

Schlissel, MS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1225

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genes encoding antigen receptors are unique because of their high diversity and their assembly in developing lymphocytes from gene segments through a series of site-specific DNA recombination reactions known as V(D)J rearrangement. This review focuses on our understanding of how recombination of immunoglobulin and T-cell receptor gene segments is tightly regulated despite being catalysed by a common lymphoid recombinase, which recognizes a widely distributed conserved recombination signal sequence. Probable mechanisms involve precise expression of the lymphoid-restricted recombination-activating genes RAG1 and RAG2, and developmentally regulated epigenetic alterations in template accessibility, which are targeted by transcriptional regulatory elements and involve chromatin-modifying enzymes.

引用

页码：890 / 899

页数：10

共 96 条

[41]

Lauring J, 1999, MOL CELL BIOL, V19, P2601

[42] Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair [J].

Lee, J ;

Desiderio, S .

IMMUNITY, 1999, 11 (06) :771-781

[43] A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival [J].

Lee, PP ;

Fitzpatrick, DR ;

Beard, C ;

Jessup, HK ;

Lehar, S ;

Makar, KW ;

Pérez-Melgosa, M ;

Sweetser, MT ;

Schlissel, MS ;

Nguyen, S ;

Cherry, SR ;

Tsai, JH ;

Tucker, SM ;

Weaver, WM ;

Kelso, A ;

Jaenisch, R ;

Wilson, CB .

IMMUNITY, 2001, 15 (05) :763-774

[44] The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development [J].

Liang, HE ;

Hsu, LY ;

Cado, D ;

Cowell, LG ;

Kelsoe, G ;

Schlissel, MS .

IMMUNITY, 2002, 17 (05) :639-651

[45] CELL-CYCLE REGULATION OF V(D)J RECOMBINATION-ACTIVATING PROTEIN RAG-2 [J].

LIN, WC ;

DESIDERIO, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2733-2737

[46] Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons [J].

Loots, GG ;

Locksley, RM ;

Blakespoor, CM ;

Wang, ZE ;

Miller, W ;

Rubin, EM ;

Frazer, KA .

SCIENCE, 2000, 288 (5463) :136-140

[47] Crystal structure of the nucleosome core particle at 2.8 angstrom resolution [J].

Luger, K ;

Mader, AW ;

Richmond, RK ;

Sargent, DF ;

Richmond, TJ .

NATURE, 1997, 389 (6648) :251-260

[48] Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development:: Implications for the control of TCR-β locus recombination [J].

Mathieu, N ;

Hempel, WM ;

Spicuglia, S ;

Verthuy, C ;

Ferrier, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (05) :625-636

[49]

Mauvieux L, 2001, EUR J IMMUNOL, V31, P2080, DOI 10.1002/1521-4141(200107)31:7<2080::AID-IMMU2080>3.0.CO

[50]

2-H

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