The cytokine and chemokine network in psoriasis

被引:153
作者
Nickoloff, Brian J. [1 ,2 ,3 ]
Xin, Hong [1 ,2 ,3 ]
Nestle, Frank O. [4 ]
Qin, Jian-Zhong [1 ,2 ,3 ]
机构
[1] Loyola Univ, Chicago Med Ctr, Dept Pathol, Maywood, IL 60153 USA
[2] Loyola Univ, Chicago Med Ctr, Skin Dis Res Program, Inst Oncol, Maywood, IL 60153 USA
[3] Loyola Univ, Chicago Med Ctr, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
[4] Kings Coll London, Sch Med, Div Genet & Mol Med, London SE1 9RT, England
关键词
D O I
10.1016/j.clindermatol.2007.08.011
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Creation and maintenance of psoriatic plaques require a multicellular conspiracy by which prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the behavior of epidermal keratinocytes and endothelial cells. These complex cellular events require coordination in space and time to achieve the mature plaque. Key molecular coordinators dictating behavior and movement of cells within plaques include cytokines as well as chemokines. These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:568 / 573
页数:6
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