Tetrahydrobiopterin radical enzymology

被引：159

作者：

Wei, CC

Crane, BR

Stuehr, DJ

机构：

[1] Cleveland Clin Fdn, Dept Immunol, Lerner Res Inst, Cleveland, OH 44195 USA

[2] Cornell Univ, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

来源：

CHEMICAL REVIEWS | 2003年 / 103卷 / 06期

关键词：

D O I：

10.1021/cr0204350

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

H4B and related tetrahydroproteins are cofactors for several enzymes and can be generators or scavangers of reactive oxygen species in cells. This review focuses on pterin radical formation in enzymes. The properties of pterin and pterin radicals that are generated in chemical systems are covered. Furthermore, function aspects of several H4B-utilizing enzymes are compared and contrasted to provide perspective for understanding H4B radical formation in enzymes.

引用

收藏

页码：2365 / 2383

页数：19

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