Natural selection and the emergence of a mutation phenotype: An update of the evolutionary synthesis considering mechanisms that affect genome variation

被引:63
作者
Caporale, LH
机构
关键词
implicit genome; Darwin; explicit genome; codon degeneracy; reversible mutations; contingency genes;
D O I
10.1146/annurev.micro.57.030502.090855
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Most descriptions of evolution assume that all mutations are completely random with respect to their potential effects on survival. However, much like other phenotypic variations that affect the survival of the descendants, intrinsic variations in the probability, type, and location of genetic change can feel the pressure of natural selection. From site-specific recombination to changes in polymerase fidelity and repair of DNA damage, an organism's gene products affect what genetic changes occur in its genome. Through the action of natural selection on these gene products, potentially favorable mutations can become more probable than random. With examples from variation in bacterial surface proteins to the vertebrate immune response, it is clear that a great deal of genetic change is better than "random" with respect to its potential effect on survival. Indeed, some potentially useful mutations are so probable that they can be viewed as being encoded implicitly in the genome. An updated evolutionary theory includes emergence, under selective pressure, of genomic information that affects the probability of different classes of mutation, with consequences for genome survival.
引用
收藏
页码:467 / 485
页数:19
相关论文
共 132 条
[51]  
Futuyma D.J., 1998, EVOL BIOL
[52]   Mutator bacteria as a risk factor in treatment of infectious diseases [J].
Giraud, A ;
Matic, I ;
Radman, M ;
Fons, M ;
Taddei, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :863-865
[53]   Generation of a strong mutator phenotype in yeast by imbalanced base excision repair [J].
Glassner, BJ ;
Rasmussen, LJ ;
Najarian, MT ;
Posnick, LM ;
Samson, LD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :9997-10002
[54]   Error-prone repair DNA polymerases in prokaryotes and eukaryotes [J].
Goodman, MF .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :17-50
[55]  
Goodman MF, 1998, GENETICS, V148, P1475
[56]   Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation [J].
Goyenechea, B ;
Milstein, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13979-13984
[57]   Virulence control in group A Streptococcus by a two-component gene regulatory system:: Global expression profiling and in vivo infection modeling [J].
Graham, MR ;
Smoot, LM ;
Migliaccio, CAL ;
Virtaneva, K ;
Sturdevant, DE ;
Porcella, SF ;
Federle, MJ ;
Adams, GJ ;
Scott, JR ;
Musser, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13855-13860
[58]   Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins [J].
Greene, CN ;
JinksRobertson, S .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (05) :2844-2850
[59]   Hyperthermophiles and the problem of DNA instability [J].
Grogan, DW .
MOLECULAR MICROBIOLOGY, 1998, 28 (06) :1043-1049
[60]  
Hadjimarcou MI, 2001, GENETICS, V158, P177