Separation of promethazine and thioridazine using capillary electrophoresis with end-column amperometric detection

被引：43

作者：

Wang, RY

Lu, XN

Wu, MJ ^{[1
]}

Wang, EK

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Electroanalyt Chem Lab, Changchun 130022, Jilin, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Natl Analyt Res Ctr Electrochem & Spect, Changchun 130022, Jilin, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B | 1999年 / 721卷 / 02期

基金：

中国国家自然科学基金;

关键词：

promethazine; thioridazine;

D O I：

10.1016/S0378-4347(98)00485-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Promethazine and thioridazine were separated and detected by capillary electrophoresis with end-column amperometric detection. The influence of pH Value on oxidation potential, the peak current and the resolution were studied and the following conditions was selected: 0.03 M Na2HPO4 and 0.015 M citric acid at pH 3.0, detection potential at 1.10 V. The detection limits of these two substances were in the range of 10(-8) mol/l. The linear range spanned two to three orders of magnitude. This method was applied to the detection of promethazine and thioridazine spiked in urine. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：327 / 332

页数：6