Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes

被引：8

作者：

Li, J. ^{[1
]}

Bergmann, A.

Reimann, M. ^{[1
]}

Schulze, J. ^{[1
]}

Bornstein, S. R. ^{[1
]}

Schwarz, P. E. H. ^{[1
]}

机构：

[1] Tech Univ Dresden, Med Fac Carl Gustav Carus, Med Clin 3, Dept Endocrinopathies & Metab Dis, D-01309 Dresden, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2008年 / 116卷 / 03期

关键词：

Neurogenin; 3; proinsulin; progression of type 2; diabetes;

D O I：

10.1055/s-2007-992156

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Transcription factor Neurogenin 3 (NGN3) is considered as a candidate gene for the development of type 2 diabetes. The aim of the current study was to investigate the relevance of NGN3 variants for the clinical spectrum of diabetes development and disease progressions. Research Design and Methods: A total of 552 subjects with increased risk of type 2 diabetes were investigated. They underwent a 75g OGTT with measurements of plasma glucose, insulin and proinsulin at fasting and at 30, 60,90 and 120 minutes after the glucose challenge, repeated after 3 years. The NGN3 SNPs, Gly167Arg and Ser199Phe were genotyped. Result: Patients with type 2 diabetes carrying the variant genotype at SNP199 presented with significantly higher proinsulin levels. Proinsulin level was also associated with progression of diabetes mellitus. There was a discrete association of the Ser199Phe variant with evolution of the disease status. Conclusion: A genetic variation in NGN3 gene may be among the genetic determinants involved in the pathogenesis of diabetes.

引用

页码：178 / 183

页数：6

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