Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules

被引：28

作者：

Chaudhary, Abha ^{[1
]}

Das, Pralay ^{[1
]}

Mishra, Awanish ^{[2
]}

Kaur, Pushpinder ^{[1
]}

Singh, Bikram ^{[1
]}

Goel, Rajesh K. ^{[2
]}

机构：

[1] Inst Himalayan Bioresource Technol, CSIR, Div Nat Plant Prod, Palampur 176061, Himachal Prades, India

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

来源：

MOLECULAR DIVERSITY | 2012年 / 16卷 / 02期

关键词：

Vinyl halide; Benzocycloheptene amino vinyl bromide derivatives; Antidepressant; Himachalene; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; POTENT; DISCOVERY; DESIGN; SERIES;

D O I：

10.1007/s11030-012-9372-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.

引用

页码：357 / 366

页数：10

共 36 条

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Enantioselective dehydrohalogenation using chiral alkoxides: Design of a catalytic system allowing access to axially dissymmetric compounds [J].