Treating Acute Kidney Injury with Antioxidative Black Phosphorus Nanosheets

被引：212

作者：

Hou, Junjun ^{[2
,4
]}

Wang, Hui ^{[1
]}

Ge, Zhilei ^{[5
,6
]}

Zuo, Tingting ^{[2
,4
]}

Chen, Qian ^{[7
]}

Liu, Xiaoguo ^{[5
,6
]}

Mou, Shan ^{[7
]}

Fan, Chunhai ^{[5
,6
]}

Xie, Yi ^{[1
]}

Wang, Lihua ^{[2
,3
]}

机构：

[1] Univ Sci & Technol China, iChEM, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China

[3] Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai 201210, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med, Shanghai 200240, Peoples R China

[6] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China

[7] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Nephrol, Shanghai 200127, Peoples R China

来源：

NANO LETTERS | 2020年 / 20卷 / 02期

基金：

中国国家自然科学基金;

关键词：

black phosphorus nanosheets; antioxidative agent; reactive oxygen species; acute kidney injury; kidney targeting drug delivery; PREVENTION; DISEASE;

D O I：

10.1021/acs.nanolett.9b05218

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Black phosphorus nanosheets (BPNSs) have been actively employed as nanomedicine agents for photothermal and photodynamic therapy by virtue of their unique optical properties. However, their chemical reactivity as a competent biomaterial has not been fully explored yet. Here, we report on the use of BPNSs as reactive oxygen species (ROS) scavengers to cure acute kidney injury (AKI) in mice. Importantly, in vivo analysis in mice revealed that BPNSs were preferably accumulated in kidney. We found that BPNSs alleviated oxidative-pressure-induced cellular apoptosis. In a ROS-triggered acute kidney injury (AKI) model, BPNSs effectively consumed ROS in kidney, demonstrating high efficacy for curing AKI. BPNSs also exhibited excellent biocompatibility and biodegradability, making them promising candidates for therapeutic treatment of AKI and other renal diseases.

引用

页码：1447 / 1454

页数：8

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