Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer

被引:1354
作者
Chen, Wansong [1 ,2 ]
Ouyang, Jiang [2 ]
Liu, Hong [1 ,3 ]
Chen, Min [2 ]
Zeng, Ke [2 ]
Sheng, Jianping [2 ]
Liu, Zhenjun [2 ]
Han, Yajing [2 ]
Wang, Liqiang [2 ]
Li, Juan [2 ]
Deng, Liu [2 ]
Liu, You-Nian [1 ,2 ]
Guo, Shaojun [4 ,5 ]
机构
[1] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China
[2] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China
[3] Cent South Univ, Aier Ophthalm Coll, Changsha 410083, Hunan, Peoples R China
[4] Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
[5] Peking Univ, Coll Engn, BIC ESAT, Beijing 100871, Peoples R China
基金
中国国家自然科学基金;
关键词
PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; ANTICANCER DRUG; GRAPHENE OXIDE; NANOPARTICLES; PLATFORM; ACCUMULATION; HYPERTHERMIA; NANOPLATFORM; CHEMOTHERAPY;
D O I
10.1002/adma.201603864
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
A black phosphorus (BP)-based drug delivery system for synergistic photodynamic/ photothermal/chemotherapy of cancer is constructed. As a 2D nanosheet, BP shows super high drug loading capacity and pH-/photoresponsive drug release. The intrinsic photothermal and photodynamic effects of BP enhance the antitumor activities. The synergistic photo-dynamic/photothermal/chemotherapy makes BP-based drug delivery system a multifunctional nanomedicine platform.
引用
收藏
页数:7
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