Break-up of Two-Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer

被引：503

作者：

Chen, Yu ^{[1
,2
,3
]}

Ye, Delai ^{[1
,2
]}

Wu, Meiying ^{[3
]}

Chen, Hangrong ^{[3
]}

Zhang, Linlin ^{[3
]}

Shi, Jianlin ^{[3
]}

Wang, Lianzhou ^{[1
,2
]}

机构：

[1] Univ Queensland, Sch Chem Engn, Nanomat Ctr, Brisbane, Qld 4072, Australia

[2] Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

[3] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 41期

基金：

澳大利亚研究理事会;

关键词：

MESOPOROUS SILICA NANOPARTICLES; MANGANESE OXIDE NANOPARTICLES; GUIDED PHOTOTHERMAL THERAPY; MULTIDRUG-RESISTANT CANCER; DRUG-DELIVERY; CONTROLLED-RELEASE; CONTRAST AGENTS; GRAPHENE; MRI; CELLS;

D O I：

10.1002/adma.201402572

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T-1-weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells.

引用

收藏

页码：7019 / +

页数：9

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