Structure-property relationships in manganese oxide - nnesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery

被引：138

作者：

Chen, Yu ^{[1
]}

Chen, Hangrong ^{[1
]}

Zhang, Shengjian ^{[2
,3
]}

Chen, Feng ^{[1
]}

Sun, Shikuan ^{[1
]}

He, Qianjun ^{[1
]}

Ma, Ming ^{[1
]}

Wang, Xia ^{[1
]}

Wu, Huixia ^{[1
]}

Zhang, Lingxia ^{[1
]}

Zhang, Linlin ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Radiol, Canc Hosp Inst, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 07期

关键词：

Magnetic resonance imaging; Manganese oxide; Mesoporous silica; Drug delivery; Diagnosis; IN-SITU SURFACTANT; MESOPOROUS SILICA; MAGNETIC-RESONANCE; CONTRAST AGENTS; CANCER-THERAPY; CELL; NANOCOMPOSITES; NANOCRYSTALS; NANOCAPSULES; TEMPLATE;

D O I：

10.1016/j.biomaterials.2011.11.086

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The extremely low longitudinal relaxivity (r(1)) of manganese oxide has severely impeded their substitution for cytotoxic gadolinium-based contrast agents for safe clinical magnetic resonance imaging (MRI). Here, we report on a synthetic strategy of chemical oxidation/reduction reaction in-situ in mesopores, followed by hydrogen reduction, for the fabrication of non-toxic manganese oxide/MSNs-based MRI-T-1 contrast agents with highly comparable imaging performance to commercial Gd-based agents. This strategy involves a "soft-templating" process to prepare mesoporous silica nanoparticles, in-situ reduction of MnO4- by the "soft templates" in mesopores and heat treatment under reducing atmosphere, to disperse manganese oxide nanoparticles within mesopores. This special nanostructure combines the merits of nanopores for maximum manganese paramagnetic center accessibility for water molecules for enhanced MRI performance and encapsulation/sustained release/intracellular delivery of drugs. The synthesized manganese oxide/MSNs were successfully assessed as a high performance contrast agent for MRI-T-1 both in intro and in vivo, and meanwhile, was also demonstrated as an effective anti-cancer drug delivery (doxorubicin) vehicle, therefore, a family of manganese-based theranostics was successfully demonstrated based on the manganese oxide/MSNs composite. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2388 / 2398

页数：11

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