PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy

被引：1158

作者：

Cheng, Liang ^{[1
]}

Liu, Jingjing ^{[1
]}

Gu, Xing ^{[1
]}

Gong, Hua ^{[1
]}

Shi, Xiaoze ^{[1
]}

Liu, Teng ^{[1
]}

Wang, Chao ^{[1
]}

Wang, Xiaoyong ^{[2
]}

Liu, Gang ^{[2
]}

Xing, Huaiyong ^{[3
]}

Bu, Wenbo ^{[3
]}

Sun, Baoquan ^{[1
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 12期

基金：

中国国家自然科学基金;

关键词：

WS2; nanosheet; CT imaging; PAT imaging; Photothermal therapy; RAY COMPUTED-TOMOGRAPHY; POLYPYRROLE NANOPARTICLES; CONVERSION EFFICIENCY; GOLD NANOPARTICLES; EXFOLIATED MOS2; GRAPHENE OXIDE; LAYER; ABLATION; NANOCOMPOSITE; NANOCRYSTALS;

D O I：

10.1002/adma.201304497

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2-PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1886 / 1893

页数：8

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