Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

被引：440

作者：

Chen, Zhigang ^{[1
,4
]}

Wang, Qian ^{[2
]}

Wang, Huanli ^{[3
]}

Zhang, Lisha ^{[3
]}

Song, Guosheng ^{[1
]}

Song, Linlin ^{[1
]}

Hu, Junqing ^{[1
]}

Wang, Hongzhi ^{[1
]}

Liu, Jianshe ^{[3
]}

Zhu, Meifang ^{[1
]}

Zhao, Dongyuan ^{[4
]}

机构：

[1] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Orthoped, Shanghai 200080, Peoples R China

[3] Donghua Univ, Coll Environm Sci & Engn, Shanghai 201620, Peoples R China

[4] Fudan Univ, Dept Chem, Adv Mat Lab, Shanghai 200433, Peoples R China

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 14期

基金：

中国国家自然科学基金;

关键词：

W18O49; nanowires; photothermal agent; 980 nm laser; ablation; cancer cells; NEAR-INFRARED ABSORPTION; REDUCED GRAPHENE OXIDE; GOLD NANORODS; CARBON NANOTUBES; THERAPY; NANOPARTICLES; NANOCRYSTALS; NANOCAGES; LIGHT; NANOSTRUCTURES;

D O I：

10.1002/adma.201204616

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 +/- 0.5 degrees C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm(-2)) for 2 min (left-hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.

引用

页码：2095 / 2100

页数：6

共 46 条

[1]

Stepwise Thermal and Photothermal Dissociation of a Hierarchical Superaggregate of DNA-Functionalized Gold Nanoparticles [J].