Copper Selenide Nanocrystals for Photothermal Therapy

被引：1315

作者：

Hessel, Colin M. ^{[1
]}

Pattani, Varun P. ^{[2
]}

Rasch, Michael ^{[1
]}

Panthani, Matthew G. ^{[1
]}

Koo, Bonil ^{[3
]}

Tunnell, James W. ^{[2
]}

Korgel, Brian A. ^{[1
]}

机构：

[1] Univ Texas Austin, Ctr Nano & Mol Sci & Technol, Texas Mat Inst, Dept Chem Engn, Austin, TX 78712 USA

[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[3] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA

来源：

NANO LETTERS | 2011年 / 11卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Copper selenide; photothermal therapy (PPT); plasmon resonance; colloidal nanocrystals; amphiphilic polymer; cancer therapy; hyperthermia; gold nanoshells; gold nanorods; photothermal transduction efficiency; QUANTUM DOTS; GOLD NANORODS; GLUCOSE-OXIDASE; CELLULAR UPTAKE; CANCER-CELLS; SURFACE; NANOPARTICLES; SIZE; NANOSHELLS; SHAPE;

D O I：

10.1021/nl201400z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ligand-stabilized copper selenide (Cu(2-x)Se) nanocrystals, approximately 16 nm in diameter, were synthesized by a colloidal hot injection method and coated with amphiphilic polymer. The nanocrystals readily disperse in water and exhibit strong near-infrared (NIR) optical absorption with a high molar extinction coefficient of 7.7 x 10(7) cm(-1) M(-1) at 980 nm. When excited with 800 nm light, the Cu(2-x)Se nanocrystals produce significant photothermal heating with a photothermal transduction efficiency of 22%, comparable to nanorods and nanoshells of gold (Au). In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 mm of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu(2-x)Se nanocrystals for photothermal therapy applications.

引用

页码：2560 / 2566

页数：7

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