Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect

被引：28

作者：

Chen, Yuan-I ^{[1
,2
]}

Peng, Cheng-Liang ^{[3
]}

Lee, Pei-Chi ^{[1
,2
]}

Tsai, Ming-Hsien ^{[1
,2
]}

Lin, Chun-Yen ^{[1
,2
]}

Shih, Ying-Hsia ^{[1
,2
,3
]}

Wei, Min-Feng ^{[1
,2
]}

Luo, Tsai-Yueh ^{[3
]}

Shieh, Ming-Jium ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10051, Taiwan

[2] Natl Taiwan Univ, Coll Engn, Taipei 10051, Taiwan

[3] Inst Nucl Energy Res, Isotope Applicat Div, Taoyuan 32546, Taiwan

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 06期

关键词：

PHOTOTHERMAL THERAPY; INDOCYANINE GREEN; DRUG-DELIVERY; IN-VITRO; NANOPARTICLES; CHEMOTHERAPY; DOXORUBICIN; DYE; SYSTEM; NANOSPHERES;

D O I：

10.1002/adhm.201400729

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near-infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)-cyanine-poly(epsilon-caprolactone) (PCL) (mPEG-Cy-PCL) are synthesized. mPEGCy-PCL are capable of performing NIRF imaging, photothermal therapy (PTT) on cancer cells and self-assembly nanocarriers. Cy-based micelles can encapsulate doxorubicin (Doxo@Cy-micelle) and achieve NIRF image-guided drug delivery. Doxo@Cy-micelles are nanosized micelles enhancing the accumulation of Doxo in tumor sites and decreasing side effects. Doxo@Cy-micelles exhibit an excellent PTT and synergistic chemotherapy of cancer via laser-triggered release of Doxo from micelles, eventually resulting in decreased cancer recurrence rates. The results show that Cy-based micelles are excellent nanocarriers for NIRF imaging and synergistic photothermal-chemotherapy of cancer.

引用

页码：892 / 902

页数：11

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